Benjamin J Buckley Selected Research

Amiloride (Midamor)

2/2022	Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity.
1/2022	An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis.
3/2021	Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors.
1/2021	Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.
12/2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease.
1/2018	6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.

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Benjamin J Buckley Research Topics

Disease

5	Neoplasms (Cancer) 10/2022 - 01/2018
2	Neoplasm Metastasis (Metastasis) 02/2022 - 01/2018
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022
1	Adenocarcinoma 01/2022
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2022
1	Inflammation (Inflammations) 01/2019
1	Rheumatoid Arthritis 01/2019

Drug/Important Bio-Agent (IBA)

8	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 10/2022 - 01/2018
6	Amiloride (Midamor)FDA LinkGeneric 02/2022 - 01/2018
4	Plasminogen Activators (Plasminogen Activator)IBA 10/2022 - 01/2018
4	DiureticsIBA 03/2021 - 01/2018
2	PlasminogenIBA 01/2022 - 01/2019
2	trypsin-like serine proteaseIBA 03/2021 - 12/2019
2	5-(N,N-hexamethylene)amilorideIBA 01/2021 - 01/2018
1	Sodium-Hydrogen ExchangersIBA 03/2021
1	Urokinase Plasminogen Activator ReceptorsIBA 01/2019
1	PotassiumIBA 01/2018
1	Peptide Hydrolases (Proteases)FDA Link 01/2018